This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
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Role of gangliosides in extracellular vesicle secretion in wild-type and Huntington's disease cell models
DownloadFall 2020
Gangliosides are sialic acid containing glycosphingolipids highly enriched in the brain that play vital roles in intercellular communication, cell signalling and calcium homeostasis. A decrease in the ganglioside levels in the brain has been associated with several neurodegenerative diseases....
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Therapeutic effects of ganlgioside GM1 and gangliomimetic compounds in multiple models of Huntington disease
DownloadSpring 2016
Huntington disease (HD) is a neurodegenerative disorder that results in motor, cognitive and psychiatric deficits. The disease is caused by the expansion of a polyglutamine stretch in huntingtin (HTT), a ubiquitous protein with unclear functions. The molecular mechanisms underlying...