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Functional characterization of urate handling by hSLC2A9 (hGLUT9) splice variants in a heterologous expression system
DownloadSpring 2012
Multiple, independent Genome Wide Association Studies have uncovered a significant correlation between abnormal plasma urate levels and single nucleotide polymorphisms within the hSLC2A9 gene. The gene product was originally characterized as a high affinity D-glucose and D-fructose transporter,...
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Synthesis and Characterization of Novel Radiolabelled Substrates for Imaging of GLUT5 Expression in Human Breast Cancer Using Positron Emission Tomography
DownloadFall 2012
Overactive glucose transport and metabolism has been widely recognized as one of the fundamental hallmarks of cancer and its progression. The facilitative glucose transporter GLUT1 is widely overexpressed in many tumor types compared to their untransformed counterparts. Due to this, the glucose...