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Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22
2013
Pfrengle, F., Kawasaki, N., Paulson, J. C. , Macauley, M. S.
Differentiation of self from nonself is indispensable for maintaining B cell tolerance in peripheral tissues. CD22 and Siglec-G (sialic acid-binding Ig-like lectin G) are two inhibitory coreceptors of the BCR that are implicated in maintenance of tolerance to self Ags. Enforced ligation of CD22...
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2014
Marcondes, Maria C. G., Macauley, Matthew S., Pang, Poh-Choo, Bortell, Nikki, Arlian, Britni M., Rillahan, Cory D., Haslam, Stuart M., Dell, Anne , Paulson, James C.
Sialic acid terminates glycans of glycoproteins and glycolipids that play numerous biological roles in health and disease. Although genetic tools are available for interrogating the effects of decreased or abolished sialoside expression in mice, pharmacological inhibition of the sialyltransferase...