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Localization and Trafficking of the Death-Inducing Fas Ligand Protein in Cytotoxic T Lymphocytes
DownloadFall 2014
Cytotoxic T lymphocytes (CTL) can kill tumor cells and cells infected with intracellular pathogens. Their two major killing mechanisms are the degranulation pathway and the Fas-FasL pathway. The degranulation process consists of the release of cytolytic perforin and granzyme molecules that are...
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Regulation of FasL expression, and delineation of differentiation states of cytotoxic lymphocytes
DownloadSpring 2015
CD8+ T cells are vital cytotoxic lymphocytes against intracellular pathogens and tumor cells. CD8+ T cells utilize a fast-acting degranulation of granzyme/perforin and slow-acting receptor:ligand, FasL:Fas, pathway of inducing target cell lysis. The importance of degranulation based target cell...