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Subcellular Investigation of Poxvirus Coinfections and the Impact on the Evolution of Cidofovir Resistance
DownloadFall 2024
The Orthopoxviruses remain important re-emerging pathogens, yet there are only two monotherapy antiviral drugs for treating infections. One of the two approved drugs is brincidofovir, which is a prodrug of the acyclic nucleoside phosphonate cidofovir (CDV). CDV inhibits the vaccinia virus DNA...
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Fall 2014
Smallpox was eradicated using vaccinia viruses (VACV) as vaccines, including Dryvax, a calf-lymph vaccine derived from the New York City Board of Health (NYCBH) strain, and TianTan, a chicken egg cultured vaccine used exclusively in China. To take advantage of the next generation sequencing...