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Skip to Search Results- 1Ahsan, Irfan.
- 1Charrunchon, Sookpichaya
- 1Engel, Megan C
- 1Foster, Daniel A N
- 1Kachur, T.M.
- 1Pilgrim, D.B.
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Fall 2013
For decades, scientists from every discipline have struggled to understand the mechanism of biological self-assembly, which allows proteins and nucleic acids to fold reliably into functional three-dimensional structures. Such an understanding may hold the key to eliminating diseases such as...
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Fall 2015
Folding of biomolecules is an important problem in structural biology. The physical folding can be projected as a diffusive search over an energy landscape whose dimensions scale by all the internal degrees of freedom which a biomolecule possesses. To explore this idea, folding is studied from...
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Myosin Assembly, Maintenance and Degradation in Muscle: Role of the Chaperone UNC-45 in Myosin Thick Filament Dynamics
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Myofibrillogenesis in striated muscle cells requires a precise ordered pathway to assemble different proteins into a linear array of sarcomeres. The sarcomere relies on interdigitated thick and thin filaments to ensure muscle contraction, as well as properly folded and catalytically active myosin...
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Fall 2013
Protein folding involves a stochastic search through the configurational energy landscape towards the native structure. Although most proteins have evolved to fold efficiently into a unique native structure, misfolding (the formation of non-native structures) occurs frequently in vivo causing a...
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Fall 2017
The formation of an abnormal form of proteins in cells can cause aggregation and neurodegenerative pathology, such as Alzheimer’s, Parkinson’s and prion diseases, which affects both humans and animals. Nowadays, the understanding of the mechanism of prion misfolding and propagation, including...