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Fall 2020
Eukaryotic cells are characterized by the presence of membrane-bound organelles. Close proximity between organelles has been observed for decades, but only recently we have really started to understand the importance of these contacts for cellular function. These contacts consist of areas of...
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Exploring the Role of Endoplasmic Reticulum Calcium Dynamics in Maintaining Cholesterol Homeostasis
DownloadFall 2018
Calreticulin is an endoplasmic reticulum (ER) protein chaperone and calcium (Ca2+) binding protein and is therefore important for maintaining ER homeostasis. Calreticulin deficiency is embryonic lethal in mice due to inadequate inositol trisphosphate receptor (InsP3R)-mediated Ca2+ signaling and...