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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Fall 2012
Melanoma has the most rapidly rising incidence of all cancers and once metastasized it is very difficult to treat. This makes the identification of molecular pathways that are deregulated in melanoma a novel area of study. β-catenin (β-cat) is a multifunctional protein of the Wnt signaling...
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Targeting a Trigger: Platelet Derived Growth Factor Receptor Alpha in the Nodal Metastasis of Papillary Thyroid Cancer
DownloadFall 2016
Recurrent, metastatic forms of papillary thyroid cancer (PTC) continue to challenge the status quo therapy regime which combines surgical resection with radioactive iodine ablation of remnant thyroid and metastatic deposits. Repetitive use of these methods following the initial failure to control...