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Fall 2023
The overarching idea of this thesis stemmed from previous work in our lab, where it was noticed that females and males exhibited different disease trajectories in a model of Multiple Sclerosis. Combined with our observation of different outcome metrics for peripheral nociception suggested that...
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The glutamate transporters' role in neuropathic pain and cognitive deficits in an animal model of multiple sclerosis
DownloadFall 2013
Multiple Sclerosis (MS) is a chronic disease of the central nervous system characterized by demyelination, inflammation and axonal injury. Chronic pain and cognitive deficits affect a large percentage of MS patients. While a number of animal models are available to study the pathophysiology of...
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Fall 2023
The immune system interacts reciprocally with the nervous system in order to accomplish facets of innate immunity via various mechanisms including toll-like receptors (TLRs). TLR activity leads to the release of cytokines which can effect acute and chronic pain states by promoting afferent neuron...