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Skip to Search Results- 14Multiple sclerosis
- 7Dopamine
- 3Experimental autoimmune encephalomyelitis
- 3Pain
- 2Exercise
- 2Inflammation
- 1Adegoke, Adeolu
- 1Asha, Anika Benozir
- 1Benson, Curtis A
- 1Catuneanu, Ana
- 1Chung, Jun-Mo.
- 1Dworsky-Fried, Zoë
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Investigation of gradient echo MRI for blood vessel imaging and susceptibility-weighted imaging in the human brain
DownloadSpring 2010
Despite the vast myriad of applications and the long way it has come, MRI is still a relatively new field of knowledge with much prospect for more advancement and expansion. This work is mainly concerned with two gradient echo imaging methods which are directly or indirectly related to blood...
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Measuring proteomic changes associated with viral infections and neurodegenerative diseases using mass spectrometry
DownloadFall 2023
Viral infection and the resultant cellular stress can trigger significant changes to the cellular host proteome. Viral proteases essential to viral replication have been shown to cleave human host protein substrates as a mechanism of immune response evasion. The severe acute respiratory syndrome...
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Fall 2009
The computational ability of principal neurons and interneurons in the brain and their ability to work together in concert are thought to underlie higher order cognitive processes such as learning, memory, and attention. Dendrites play a very important role in neuronal information processing...
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Pain and analgesia in experimental autoimmune encephalomyelitis: Contribution of the central nucleus of the amygdala
DownloadSpring 2021
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation, degeneration and demyelinating lesions within the central nervous system. Chronic pain is a highly prevalent symptom associated with MS, affecting 50-80% of patients over the course of their disease....
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Promoting Activity Behaviour in Adults with Multiple Sclerosis: Feasibility, Preliminary Efficacy and Evaluation of Activity Measurement Tools
DownloadFall 2021
Background: Multiple sclerosis (MS) is the largest cause of non-traumatic neurological disability in young adults. Canada has one of the highest rates of MS in the world, with nearly 1 in every 385 Canadians living with the disease. People with MS deal with a broad range of symptoms including...
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Spring 2023
Recent thymic emigrants (RTE) are newly generated T cells that have just been exported to the periphery, where they continue their maturation to become mature T cells. RTE have only undergone central tolerance in the thymus but not yet undergone peripheral tolerance. As such, it is imperative...
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Sex Differences in Central Nervous System Plasticity and Pain in Experimental Autoimmune Encephalomyelitis
DownloadSpring 2019
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system (CNS). A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development...
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The Effect of Dopamine on Pulmonary Diffusing Capacity and Capillary Blood Volume Responses to Exercise
DownloadFall 2017
Pulmonary diffusing capacity increases during exercise to meet the increasing oxygen (O2) demand of the body. Expansion of pulmonary capillary blood volume (Vc) and diffusing membrane capacity (Dm) are important contributors to the increased diffusing capacity observed during upright cycle...
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The pulmonary vasculature during exercise in health and mild chronic obstructive pulmonary disease
DownloadFall 2017
The purpose of this dissertation was to characterize the response of the pulmonary vasculature to exercise in health (including a pharmacological intervention) and in individuals with mild chronic obstructive lung disease. The first project studied the effect of a dopamine receptor blockade on...