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Development of Novel Models to Study Sub and Post Cellular Uptake of Drugs Following Oral Administration
DownloadFall 2024
Given the numerous benefits of oral administration, this thesis investigates two key phenomena influencing the pharmacokinetics and pharmacodynamics of orally administered active pharmaceutical ingredients (APIs): lysosomal trapping and intestinal lymphatic uptake via chylomicrons, with a...
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Erding formula and bioactive markers in hyperuricemia: towards rational scientific approaches for the modernization of Traditional Chinese Medicine
DownloadSpring 2019
Introduction: Traditional Chinese Medicine (TCM) represents one of the first holistic approaches in the world to treat and prevent disease. Herbal medicine is one of the major therapeutic remedy in TCM. It often involves multi-herb therapies instead of single herb preparations. Parallel to...
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Mechanistic Dissolution Modeling of a Poorly Soluble Drug; an Evaluation of Formulation Influence and Simulation Parameters for Enhancing Predictive Capability
DownloadFall 2019
In early drug development, the selection of a formulation platform and decisions on formulation strategies have to be made within a short timeframe and often with minimal use of the active pharmaceutical ingredient (API). At this stage, there is limited information available about the...
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Fall 2010
The microstructures and performance of Ni-based alloys and Ni-WC (nickel-tungsten carbide) composite overlays deposited by plasma transferred arc welding have been studied. The Ni-alloy overlays had similar microstructures consisting of Ni dendrites, with interdendritic Ni-based eutectics,...
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The Dissolution Behavior of Ibuprofen and Griseofulvin in Bicarbonate Buffer Compared to Phosphate Buffer Using Intrinsic Dissolution Rate and Biphasic Dissolution
DownloadFall 2018
In the small intestine, bicarbonate is the main buffering system to adjust the pH after the gastric emptying to pH 5.5-6.8. Bicarbonate gathered some attention to be used as a dissolution media to better mimic the in-vivo environment. However, in vitro the evaporation of CO2(g) interferes with...