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Skip to Search Results- 1Almukainzi, May Khalifah
- 1Ben-Eltriki,Mohamed Ahmed
- 1Chaudhary, Hetal R
- 1El Sayed, Dalia
- 1Featherstone, Travis R
- 1Gabr,Raniah Q
- 2Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 2Dr. Dion R. Brocks, Faculty of Pharmacy and Pharmaceutical Sciences
- 1Dr. Brocks, Dion R (Faculty of Pharmacy and Pharmaceutical Sciences
- 1Dr. Scot Simpson (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Eurich, Dean (Public Health)
- 1Necyk, Candace (Faculty of Pharmacy and Pharmaceutical Sciences)
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Fall 2012
Cardiometabolic syndrome refers to a clustering of several risk factors for cardiovascular disease; obesity and hyperlipidemia are two underlying disorders associated with the syndrome. An often overlooked aspect of these conditions is the effect that they may have on the pharmacokinetics of...
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Exploring the Relationship Between Depression and Adherence in Individuals with Type 2 Diabetes
DownloadFall 2020
Background: Depression is a well-known risk factor for poor medication adherence in individuals with diabetes; however, this association is based on cross-sectional and cohort studies measuring adherence after depression is diagnosed. Symptoms of depression often progress before medical...
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Mechanisms of Pharmacists Interventions on Medication Management and Adherence in Patients with Type 2 Diabetes
DownloadSpring 2014
Optimal management of type 2 diabetes requires a collaborative, team-based approach; however, the role of pharmacists on these teams has not been well-defined. In the first study of this thesis, a systematic review examined components of pharmacist interventions to improve adherence to oral...
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Fall 2016
Seniors requiring advanced care and supports are often residing in residential care facilities (RCF). Although, up to 33% of the residents are living with known diabetes, administrators and clinicians are faced with two important questions: 1) what is the prevalence of undetected diabetes; and,...
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The application of computer simulation to investigate drug absorption and bioavailability in disease states
DownloadFall 2015
Oral drug absorption relies mainly on the physicochemical drug properties and the interaction with the physiological environment of the body. These factors could be altered significantly under abnormal conditions and disease states. Identifying these changes can optimize drug therapy under these...
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The effect of oral lipids and lipoproteins on the biodistribution, metabolism and electrocardiographic side-effects of halofantrine
DownloadSpring 2011
In the past, hyperlipidemia (HL) has been shown to affect the pharmacokinetic and pharmacodynamic properties of lipophilic drugs extensively bound to lipoproteins, including halofantrine (HF). The present thesis examined the effect of HL on the biodistribution, metabolism and electrocardiographic...
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The Effects of Elements of Cardiometabolic Syndrome on Metformin Disposition: Obesity and Hyperlipidemia
DownloadFall 2015
The influences of obesity, Roux-en-Y gastric bypass bariatric (RYGB) surgery and hyperlipidemia on metformin pharmacokinetics (PK) were investigated. A sensitive and novel HPLC-UV reverse phase assay method was developed and utilized. Detection and mass characterization for metformin metabolites...
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The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole
DownloadFall 2010
The influence of hyperlipidemia on the pharmacodynamic and pharmacokinetic aspects of lipophilic drugs was explored. The antiarrhythmic, amiodarone, and the antifungal, (±)-ketoconazole, were used as model drugs. Experimental hyperlipidemia was induced in rat using poloxamer 407 and two sensitive...
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The poloxamer 407 induced hyperlipidemic rat model and its effect on renal toxicity of calcineurin inhibitors
DownloadFall 2012
The present study characterized poloxamer 407 (P407) induced hyperlipidemia in rats and investigated its effect of on renal toxicity of the immunosuppressants tacrolimus and cyclosporine A. P407 (0.5 or 1 g/kg) was injected in rats and blood samples were collected at different time-points....