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Development and Applications of Quantitative Mass Spectrometric Methods for Proteome and Protein Analysis
DownloadSpring 2013
Quantitative proteomics has been increasingly recognized as a key research topic in proteomics research, as it enumerates changes of proteins’ expression level in a bio-system. Quantitative proteomics provides an important way to discover biomarkers for disease diagnosis and prognosis, and also...
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Development of Chemical Isotope Labeling (CIL) LC-MS Techniques for Untargeted Analysis Milk Metabolomics and Targeted Analysis of Propionic Acid
DownloadFall 2017
Metabolomics is the study of all the small molecules in a given sample or organism. It is used to understand individual variations caused by the relationship between the individual’s genetics, exposome and metabolic activity. There is interest in using metabolomics for personalized care leading...
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Spring 2016
The analysis of thousands of metabolites and lipids for discovery of metabolite biomarkers for disease monitoring and diagnosis requires the highest sensitivity and robust methods. Metabolomics is the study of metabolites found in the body, which can be used to discover biomarkers of disease or...
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Evaluation of Derivatization Reaction Conditions for Metabolite Labelling Using Differential Isotopic Labelling for Biological Samples Analyzed by Liquid Chromatography Mass Spectrometry
DownloadFall 2013
The objective of this work was to assess the impact of reaction conditions for isotopic labeling of metabolites prior to analysis using liquid chromatography mass spectrometry (LC-MS). Differential isotope 12C/13C dansyl chloride was used to label metabolites containing either primary amines,...