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Skip to Search Results- 2Cytochrome P450
- 1Arsenic trioxide
- 1Aryl hydrocarbon receptor
- 1CYP1B1
- 1Cardiac hypertrophy
- 1Eicosanoids
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Modulation of Aryl Hydrocarbon Receptor (AHR)-Regulated Metabolic Enzymes by Arsenic Trioxide and its Thioarsenical Metabolite
DownloadFall 2024
Arsenic trioxide (ATOIII) has evolved into a successful therapy for acute promyelocytic leukemia (APL), however, being an arsenical, it retains at its core the hypertoxic characteristics of that notorious metalloid. Such inherent toxicity causes a constellation of complications in APL patients,...
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Spring 2024
Heart failure (HF) is typically preceded by cardiac hypertrophy (CH), which is characterized by cardiomyocytic enlargement following stress. During CH development, expression of cytochrome P450 enzymes (CYPs) and metabolism of arachidonic acid (AA) are altered. Cardiac CYPs metabolize AA into...