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Fall 2015
Vertebrate eye development is a dynamic process that couples morphogenesis, migration of extraocular periocular mesenchyme (POM) cells to the eye, and retinal patterning along the nasotemporal and dorsoventral (DV) axes. Aberrant patterning during ocular development often results in defects...
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Spring 2020
Ocular coloboma is a congenital disorder that presents as an ocular malformation in the inferior aspect of the eye and may result in blindness. Recently, our lab characterized a novel disorder, superior coloboma, which presents as a coloboma affecting the superior portion of the eye. We...
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Fall 2019
Axial patterning of the developing vertebrate eye is crucial for proper axon pathfinding, as well as critically important morphogenetic events such as closure of the ocular fissure. Perturbations in eye morphogenesis can lead to ocular coloboma (failed ocular fissure closure) and microphthalmia...