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Insights into Membrane Type-1 Matrix Metalloproteinase cleavage of the Low-density Lipoprotein Receptor
DownloadSpring 2021
The Low-density lipoprotein receptor (LDLR) mediated cellular uptake of LDL is the main pathway for plasma LDL cholesterol (LDL-C) clearance. However, the LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into the extracellular milieu and as such reducing its LDL-C...
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Fall 2013
Despite many decades of research and drug development, the diseases of the cardiovascular system remain a major health threat in the modern world. Hypertensive cardiac disease is a cardiovascular condition characterized by the co-occurrence of hypertension and pathological cardiac remodeling...
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