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Fall 2019
The development of efficacious anticancer therapies has significantly improved the prognosis of childhood cancer patients at the price of predisposing survivors to extensive chronic health problems. Although not fatal, reducing treatment-related hearing loss (ototoxicity) among childhood cancer...
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Improving chemotherapeutic regimens by mitigating hearing loss as a limiting side-effect and examining transition metal ions as a ligand for zebrafish Tlr4
DownloadFall 2023
Cancer is often a debilitating disease associated with the uncontrolled growth of cells within an organism. We have made significant strides over the past few decades in treating many cancers, unfortunately, many of these treatments have unfavourable side effects. Cisplatin is a revolutionary...
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Rational Design and Development of Nanodelivery Systems and Combination Treatments for Overcoming Chemoresistance in Solid Tumors
DownloadFall 2017
The long term goal of this research is to develop drug delivery systems and combination treatments that can overcome chemoresistance in breast cancer. Here, we attempted two different approaches: First, we tried development of polymeric micelles capable of enhanced drug delivery to tumor, while...
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Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein; and zebrafish as a model for cisplatin induced ototoxicity and transition metals as potential ligands for Tlr4ba and Tlr4bb
DownloadFall 2021
The work presented in this thesis is split between two projects. The first utilises prp1 and prp2 knockout zebrafish to investigate physiological functions of the cellular prion protein (PrPC). The second builds upon the use of zebrafish as a model for hearing loss to confirm a role of toll-like...