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Mechanisms of T Cell Dysfunction in Chronic Lymphocytic Leukemia and Viral Associated Carcinoma
DownloadFall 2023
T cell exhaustion compromises anti-tumor immunity, and a sustained elevation of coinhibitory receptors is a hallmark of T cell exhaustion in solid tumors. Similarly, upregulation of co-inhibitory receptors has been reported in T cells in hematological cancers such as chronic lymphocytic leukemia...
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Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia
DownloadFall 2024
Background: CD8+ T cells, in particular, those expressing the co-stimulatory molecule CD226, play crucial roles against malignancies. However, their role in chronic lymphocytic leukemia (CLL), which is an immunosuppressive disease, has yet to be explored. Therefore, further studies are needed to...