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Skip to Search Results- 1Benjaminy, Shelly
- 1Freund, Paul R
- 1Githaka, John M
- 1Harbison, Adrian Mark.
- 1Howlader, Md Amran
- 1Ling, Jennifer YM
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Fall 2017
Prion disease, or transmissible spongiform encephalopathy (TSE), is a type of neurodegenerative disease for which there is no treatment and which is invariably fatal. Prion diseases are distinct in the field of biology and medicine, not only because they can be sporadic, infectious, or inherited,...
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Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
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Fall 2013
West Nile virus (WNV) is a neurotropic, blood-borne flavivirus that can cause serious neurological disease in humans and animals. While significant progress has been made in identifying virus-encoded pathogenic determinants, very little is known regarding how these viral proteins interact with...
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Spring 2018
Choroideremia is an X-linked monogenic inherited retinal disease. It affects males starting in their teenage years with night blindness followed by progressive vision loss starting in the peripherals and ending with total vision loss late in life. It is estimated that 1 in 50,000 individuals...
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Spring 2020
The human neuraminidases (NEU1, NEU2, NEU3, and NEU4) are a family of enzymes implicated in pathologies including cancer and diabetes. Our group has developed selective inhibitors for these enzymes that have been employed as tools to understand their biological roles. Several reports have linked...
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Ocular gene transfer communications: Developing ethical frameworks for phase I choroideremia clinical trials
DownloadSpring 2013
I investigate how to ethically communicate about a phase I gene transfer trial for choroideremia, a blinding retinopathy, in light of this novel biotechnology’s portrayal as a potential ‘cure’. I analyzed gene transfer communications in three contexts: (1) interviews with clinicians (n=15),...
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Plasma Membrane Organization and Endocytosis of CD36 in Human Microvascular Endothelial Cells
DownloadSpring 2016
The plasma membrane is a dynamic lipid bilayer that surrounds the cell, embedded with different plasma membrane proteins, aiding communication between the inside and outside of the cells. Its functions are achieved through an intricate organization of lipid-lipid, lipid-protein and...
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Fall 2017
Protein prenylation is the post-translational addition of isoprenoid lipid moieties to proteins, which regulates their subcellular localization and function. Farnesyl or geranylgeranyl isoprenoids are covalently linked to cysteines residues in a C-terminal prenylation recognition sequence in...
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Fall 2014
Choroideremia (CHM) is an inherited X-linked retinal dystrophy that causes hemizygous males to develop nyctalopia and a progressive loss of their peripheral visual field until only central vision remains. At the end stages of the degeneration, central acuity is also affected. The onset and rate...