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Spring 2019
Phosphatidylcholine (PC), the most abundant phospholipid in eukaryotic cells, is an important component of cellular membranes and lipoprotein particles. The enzyme CTP: phosphocholine cytidylyltransferase (CT) regulates de novo PC synthesis in response to changes in membrane lipid composition in...
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Fall 2016
Choline is an essential micronutrient with increased requirements during pregnancy and lactation due to a high demand by the developing fetus and infant. Animal studies have demonstrated that choline is essential for brain development, and as a component of all cell membranes it is hypothesized...
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Fall 2017
Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme that converts phosphatidylethanolamine to phosphatidylcholine. Pemt-/- mice are protected from obesity and insulin resistance, a phenotype that is reversed with dietary choline supplementation. Additionally, PEMT deficiency...
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Fall 2021
Choline, as an essential nutrient, is needed for a variety of biological processes such as phospholipid synthesis, cell-membrane signaling, lipoprotein secretion, acetylcholine biosynthesis, and one-carbon metabolism. In the North American population diet the two most common forms of choline in...