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Skip to Search Results- 7Fliegel, Larry
- 3Amith, Schammim Ray
- 2Baksh, Shairaz
- 2Wilkinson, Jodi Marie
- 1Fong, Sunny
- 1Kemp, Grant
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Dimeric structure of human na+/H+ exchanger isoform 1 overproduced in saccharomyces cerevisiae
Download2008-01-01
Moncoq, Karine, Kemp, Grant, Li, Xiuju J., Fliegel, Larry, Young, Howard S.
The Na+/H+ exchanger isoform 1 (NHE1) is an integral membrane protein that regulates intracellular pH by extruding an intracellular H+ in exchange for one extracellular Na+. The human NHE1 isoform is involved in heart disease and cell growth and proliferation. Although details of NHE1 regulation...
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Mitogen-activated protein kinase-dependent activation of the na+/H+ exchanger is mediated through phosphorylation of amino acids ser(770) and ser(771)
Download2007-01-01
Malo, Mackenzie E., Li, Liang, Fliegel, Larry
We investigated regulation of the type 1 isoform of the Na+/H+ exchanger by phosphorylation. Four specific groups of serine and threonine residues in the regulatory carboxyl-terminal tail were mutated to alanine residues: group 1, S693A; group 2, T718A and S723A/S726A/S729A; group 3,...
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Na+/H+ exchange in the tumour microenvironment: Does NHE1 drive breast cancer carcinogenesis?
Download2015-01-01
Amith, Schammim Ray, Fong, Sunny, Baksh, Shairaz, Fliegel, Larry
Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading cause of patient mortality. The aberrant metabolic, proliferative and anti-apoptotic nature of neoplastic cells can be traced to the abnormal expression of their ion transporters and related...
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Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells
Download2016-01-01
Amith, Schammim Ray, Wilkinson, Jodi Marie, Fliegel, Larry
In triple-negative breast cancer (TNBC), the high recurrence rate, increased invasion and aggressive metastatic formation dictate patient survival. We previously demonstrated a critical role for the Na+/H+ exchanger isoform 1 (NHE1) in controlling metastasis of triple-negative cells. Here, we...
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Protein Kinase Mediated Regulation of the Na+/H+ Exchanger in the Rat Myocardium by MAP-Kinase-dependent Pathways
Download1999-01-01
Moor, Andrea Noor, Fliegel, Larry
We examined regulation of the Na+/H+ exchanger isoform 1 by phosphorylation in the rat myocardium. We utilized cell extracts from adult rat hearts, adult rat extracts fractionated by fast performance liquid chromatography, and extracts from cultured neonatal cardiac myocytes. The...
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The na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells
Download2015-01-01
Amith, Schammim Ray, Wilkinson, Jodi Marie, Baksh, Shairaz, Fliegel, Larry
Dysregulation of Na+/H+ exchanger isoform one (NHE1) activity is a hallmark of cells undergoing tumorigenesis and metastasis, the leading cause of patient mortality. The acidic tumor microenvironment is thought to facilitate the development of resistance to chemotherapy drugs and to promote...