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Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate Shiga toxin and serum amyloid P component ternary complex formation.
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Mulvey, G. L., Bundle, D. R., Deng, Z., Armstrong, G. D., Sadowska, J .M., Paszkiewicz, E., Griener, T., Ahmed, M., Narain, R., Kitov, P. I.
Inhibition of AB(5)-type bacterial toxins can be achieved by heterobifunctional ligands (BAITs) that mediate assembly of supramolecular complexes involving the toxin's pentameric cell membrane-binding subunit and an endogenous protein, serum amyloid P component, of the innate immune system....