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Skip to Search Results- 2Cardiac fibrosis
- 1Angiotensin II
- 1Cardiac hypertrophy
- 1ECM Remodeling,
- 1Heart Failure,
- 1Hypertension
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Differential Roles of the Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) in Heart Failure
DownloadFall 2017
Considering the morbidity and mortality associated with heart failure, there is an increasing demand to develop new therapeutic alternatives for cardiac diseases. Advanced left ventricular remodeling following ischemic and pressure-overload cardiomyopathy causes changes in LV geometry, myocyte...
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Spring 2011
Angiotensin II signals cardiovascular disease through metalloproteinases including MMP-2, MMP-7 and ADAM-17/TACE. We hypothesized that these metalloproteinases regulate each other at the transcriptional level. Further, MMP-2, being a major gelatinase in cardiac and vascular tissue, could mediate...