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16R-HETE and 16S-HETE Alter Human Cytochrome P450 1B1 through Transcriptional and Allosteric Mechanism
DownloadFall 2022
Cardiac hypertrophy is a complex anomaly of the heart associated with increased muscle mass and thickening of the cell walls in response to accumulative stress. Although this condition occurs naturally, the prolonged state will progress into heart failure or even cause death. Recent studies have...
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The effect of fluconazole on cytochrome P450 1B1, formation of arachidonic acid metabolites, and protection against angiotensin II-induced cardiac hypertrophy
DownloadFall 2018
Several studies have elucidated the role of cytochrome P450s (CYPs) and their associated arachidonic acid (AA) metabolites in development of cardiac hypertrophy. CYP1B1 has been reported to have a major role in metabolizing AA into cardiotoxic metabolites, mid-chain hydroxyeicosatetraenoic acid...
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The Role of Subterminal Hydroxyeicosatetraenoic Acids in the Pathogenesis of Cardiac Hypertrophy
DownloadFall 2021
Cardiac hypertrophy is a complex condition which is characterized by increased mass of the heart muscle. If untreated, cardiac hypertrophy can ultimately lead to heart failure (HF), arrhythmia and sudden death. Accumulating evidence suggest that pathological cardiac hypertrophy is strongly...