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Skip to Search Results- 1Brophy, Taylor Raymond
- 1Buijs, David, M
- 1Cheng Baron, June
- 1Chu, Kevin
- 1Clifford, Alexander M
- 1Collins, Catherine Elizabeth Victoria
- 6Department of Agricultural, Food, and Nutritional Science
- 3Department of Biological Sciences
- 3Department of Medicine
- 2Department of Medical Microbiology and Immunology
- 2Department of Physiology
- 2Faculty of Pharmacy and Pharmaceutical Sciences
- 1Baker, Glen (Psychiatry)
- 1Davidge, Sandra T. (Physiology/Obstetrics and Gynecology)
- 1Dr. Andrew Mason (Medicine)
- 1Dr. David Bressler (Agricultural, Food and Nutritional Science)
- 1Dr. Dion R. Brocks, Faculty of Pharmacy and Pharmaceutical Sciences
- 1Dyck, Jason RB (Pediatrics)/ McAlister, Finlay A (Medicine)
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Fall 2023
The calving transition is a challenging period for dairy cows characterized by negative energy balance, metabolic dysfunction, and inflammation, each of which may compromise milk production. Despite extensive research in this area, much is still unknown on how to best manage this period. The...
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Long-term cardiovascular and metabolic effects of hypoxia-induced intrauterine growth restriction
DownloadSpring 2011
Rueda-Clausen, Christian Federico
Cardiovascular and metabolic diseases are still the primary cause of death and disability in modern society. Although genetic factors play a fundamental role in the development of these chronic conditions, the remarkable variability in an individual’s susceptibility to develop these pathologies...
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Spring 2022
Dendritic cells (DCs) are antigen presenting cells critical for the initiation of the adaptive immune response. As such, DCs continually circulate the body to survey for foreign antigen in the periphery. DCs encounter a milieu of environmental cues within the traversed microenvironment that can...
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Fall 2019
Parasite aggregation is a population-based metric in which many hosts harbour few parasites but some hosts are infected by a large number of parasites. The causes of aggregation are primarily attributed to heterogeneity in host exposure and susceptibility. However, parasites can exert numerous...
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Fall 2013
Collins, Catherine Elizabeth Victoria
Surface mining for bitumen extraction results in production of tailings that are deposited into large ponds. Tailings in the ponds support diverse microbial communities capable of metabolizing organic compounds and producing biogenic gases (methane, CH4 and carbon dioxide, CO2). Because of low...
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Myeloperoxidase-mediated bio-activation of NSAIDs in leukemia cells: Potential selective cytotoxicity
DownloadFall 2019
Several lines of evidence have pointed to the potential benefit of anti-inflammatory drugs (NSAIDs) in cancer therapy due to the well-established correlation between cancer and chronic inflammation. Acute myeloid leukemia (AML) cells overexpress myeloperoxidase (MPO), which has been studied for...
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New Insight into the Role of Myocardial Fatty Acid Uptake and Utilization in Health and Disease
DownloadFall 2013
All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply...
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Nutritional Factors Impacting Intestinal Lipid Metabolism Using a Model of Low Birth Weight Swine
DownloadSpring 2018
Introduction: Non-communicable diseases (NCDs) such as obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) are increasing at an alarming rate globally. A common feature in these conditions is increased adiposity leading to insulin resistance (IR). Dyslipidemia is a major contributing...
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Spring 2013
Diastolic dysfunction is the primary cause of 40–50% of all heart failure cases and is a contributing factor in many cardiac conditions, resulting from delayed or slowed muscle relaxation, increased stiffness of the relaxed heart or from poor systolic function which reduces the elastic recoil of...