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Skip to Search Results- 1Buijs, David, M
- 1Cheng Baron, June
- 1Halpin, Anne M
- 1Nagendran, Jeevan
- 1Perri, Melissa
- 1Rueda-Clausen, Christian Federico
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A Novel Comparative Analysis Approach to Personalize Chemotherapy Dose Calculation in Early Breast Cancer
DownloadFall 2018
Background Worldwide, body surface area [BSA] is used to calculate chemotherapy dose. The BSA formula was originally developed in 1916, derived from height and weight, with no consideration of other patient characteristics. Most chemotherapy agents have a narrow therapeutic index and are...
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Fall 2016
Multiple sources suggest that insulin resistance and derangements of cardiac metabolism are among the earliest signs of type-2 diabetes detected in the heart. Unfortunately, limited evidence reflects early changes in cardiac mitochondrial metabolism linked to the development of this disease....
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Fall 2022
Background: Although pediatric heart transplantation is a life-saving and effective therapy for children with cardiac disease, barriers remain due to a lack of available organs as well as transplant failure due to rejection. This dissertation aimed to increase knowledge related to immune risk...
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Long-term cardiovascular and metabolic effects of hypoxia-induced intrauterine growth restriction
DownloadSpring 2011
Rueda-Clausen, Christian Federico
Cardiovascular and metabolic diseases are still the primary cause of death and disability in modern society. Although genetic factors play a fundamental role in the development of these chronic conditions, the remarkable variability in an individual’s susceptibility to develop these pathologies...
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New Insight into the Role of Myocardial Fatty Acid Uptake and Utilization in Health and Disease
DownloadFall 2013
All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply...
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Spring 2013
Diastolic dysfunction is the primary cause of 40–50% of all heart failure cases and is a contributing factor in many cardiac conditions, resulting from delayed or slowed muscle relaxation, increased stiffness of the relaxed heart or from poor systolic function which reduces the elastic recoil of...
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Spring 2013
Background: Exercise adherence is particularly low among elderly patients with low functional capacity. Purpose: This study was undertaken to assess the relationship between measures of physical function (PF) with physical activity (PA) in elderly cardiac patients. Methods: PF was assessed in...