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Skip to Search Results- 1Airo, Adriana M
- 1Cairo, Christopher W.
- 1Howlader, Md Amran
- 1Howlader, Md. Amran
- 1Jia, Feng
- 1Urbanowski, Matthew D.
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...
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Fall 2020
Despite their small size and apparent simplicity, viruses are capable of causing mass casualties, political turmoil, and global economic shut down. Due to their minimal genome (~10–12 kb), arboviruses such as Zika (ZIKV), Dengue (DENV), and Mayaro (MAYV) depend on many host molecules for...
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Fall 2013
West Nile virus (WNV) is a neurotropic, blood-borne flavivirus that can cause serious neurological disease in humans and animals. While significant progress has been made in identifying virus-encoded pathogenic determinants, very little is known regarding how these viral proteins interact with...
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2016-06-22
Jia, Feng, Howlader, Md. Amran, Cairo, Christopher W.
Integrins are critical receptors in cell migration and adhesion. A number of mechanisms are known to regulate the function of integrins, including phosphorylation, conformational change, and cytoskeletal anchoring. We investigated whether native neuraminidase (Neu, or sialidase) enzymes which...
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Spring 2020
The human neuraminidases (NEU1, NEU2, NEU3, and NEU4) are a family of enzymes implicated in pathologies including cancer and diabetes. Our group has developed selective inhibitors for these enzymes that have been employed as tools to understand their biological roles. Several reports have linked...