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Skip to Search Results- 1Abdulsalam Alharbi
- 1Alshamsan, Aws
- 1Binkhathlan, Ziyad
- 1Elshaikh, Asya S Egweda
- 1Molavi, Ommoleila
- 1Rodriguez Dimitrescu, Alexandra
- 3Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Brocks, Dion R. (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Carlos, Velázquez-Martínez (Pharmacy and Pharmaceutical Sciences)
- 1El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Lavasanifar, Afsaneh (Pharmacy and Pharmaceutical Sciences)
- 1Löbenberg, Raimar (Faculty of Pharmacy and Pharmaceutical Sciences)
Results for "departments_tesim:"Faculty of Pharmacy and Pharmaceutical Sciences""
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Spring 2020
Tabatabaei Dakhili, Seyed Amirhossein
Thousands of transcription factors control the process of gene expression and protein synthesis in the human body. These nuclear proteins are fundamental for healthy organ development, cellular function, immunity and body response to diseases and stress. Mutated, overexpressed, or dysregulated...
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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Development of block copolymer based nanocarriers for the solubilization and delivery of valspodar
DownloadFall 2011
One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR), where cancer cells become resistant to different types of anticancer drugs. Over-expression of membrane efflux pumps like P-glycoprotein (P-gp), which recognizes different chemotherapeutic agents and...
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Development of Novel Polymeric Micellar DACHPt for Enhanced Platinum Based Chemotherapy in Colorectal Cancer
DownloadSpring 2019
One of the major limitations of chemotherapy in cancer treatment is the side effects of anti-cancer drugs. This happens due to non-selective distribution of most standard chemotherapies, and their action on cancer and all normal dividing cells. The objective of this project is to develop a novel...
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Fall 2010
In many tumors, persistently-active signal transducer and activator of transcription 3 (STAT3) imparts several oncogenic features such as survival, proliferation, angiogenesis, and immune escape. Therefore, STAT3 targeting in cancer and cancer-exposed dendritic cells (DCs) is important for cancer...
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Downregulation of the FOXM1 transcription factor by dual nitric oxide-/ hydrogen sulfide-donors: preliminary structure-activity relationships
DownloadFall 2015
Rodriguez Dimitrescu, Alexandra
In recent decades, the Forkhead Box (FOX) family of transcription factors (e.g. FOXM1) has attracted the attention of the scientific community due to its significant role in cancer initiation and progression. Furthermore, the abnormal or deregulated expression of FOXM1 has been associated with...
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Preliminary validation of a computer-based approach to find new lead molecules targeting the oncogenic Forkhead box M1 transcription factor
DownloadFall 2017
The upregulation of the forkhead box M1 (FOXM1) transcription factor is directly correlated with cancer initiation, invasion, and drug resistance. Because the overexpression of FOXM1 is considered an important factor in carcinogenesis, this protein could be a relevant drug target in cancer...
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Repositioning study of flubendazole for treating lung cancer and meningoencephalitis using an oral lipid nanosystem
DownloadFall 2023
Nanoemulsions have wide application, presenting several properties such as the solubilization of poorly soluble drugs in water, promoting the increase of their bioavailability, allowing greater stability of the formulation and, due to its property as a carrier, promoting their modified release....