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Fall 2012

Panaitescu, Bogdan Alexandru

Apnea of prematurity is a common problem among the infants born before term pregnancy. Administration of respiratory stimulating drugs methylxanthines is the most frequent therapy, often in combination with the use of intubation. Opioids are used to reduce the pain associated with intubation,...

Fall 2022

Waselenchuk, Quinn

The locus coeruleus (LC) is a small brainstem nucleus that controls diverse behaviours and brain functions via release of noradrenaline (NA) in the neonatal time period. There is increasing evidence of complexity in this neuron-astrocyte ‘neural’ network that remains mostly unexplored in...

Fall 2017

Shulhan, Jocelyn R

Necrotizing enterocolitis (NEC) is a potentially life-threatening inflammatory disease of the gut affecting newborns, especially preterm infants. This complex disease is affected by numerous risk factors including genetics, intestinal microbiota, immune system responses, cardiac or respiratory...

Spring 2018

Lavallee, Celeste M

Neonates with intestinal failure (IF), who must rely on parenteral nutrition (PN) for growth and maintenance of health, are at risk for intestinal failure-associated liver disease (IFALD). In neonates, short bowel syndrome (SBS) as a result of intestinal resection is the most common cause of IF....

Fall 2012

Kantor, Chase M

Spontaneous neuronal bursting appears to be pivotal for brain maturation. This thesis studied such synchronized neural network oscillations in immature newborn rat hippocampus, cortex, and locus coeruleus. For this, horizontal brain slices were generated for (simultaneous) suction electrode...

Spring 2019

Rawal, Bijal

The locus coeruleus (LC) in the pons of the brainstem provides the sole source of noradrenergic afferent input to most brain structures including the cerebral cortex, hippocampus, cerebellum and spinal cord. The resulting modulation of activity is important for controlling behaviors like...