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16R-HETE and 16S-HETE Alter Human Cytochrome P450 1B1 through Transcriptional and Allosteric Mechanism
DownloadFall 2022
Cardiac hypertrophy is a complex anomaly of the heart associated with increased muscle mass and thickening of the cell walls in response to accumulative stress. Although this condition occurs naturally, the prolonged state will progress into heart failure or even cause death. Recent studies have...
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Spring 2024
Heart failure (HF) is typically preceded by cardiac hypertrophy (CH), which is characterized by cardiomyocytic enlargement following stress. During CH development, expression of cytochrome P450 enzymes (CYPs) and metabolism of arachidonic acid (AA) are altered. Cardiac CYPs metabolize AA into...
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The effect of fluconazole on cytochrome P450 1B1, formation of arachidonic acid metabolites, and protection against angiotensin II-induced cardiac hypertrophy
DownloadFall 2018
Several studies have elucidated the role of cytochrome P450s (CYPs) and their associated arachidonic acid (AA) metabolites in development of cardiac hypertrophy. CYP1B1 has been reported to have a major role in metabolizing AA into cardiotoxic metabolites, mid-chain hydroxyeicosatetraenoic acid...