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Fall 2024
The chloride intracellular channel (CLIC) isoform 5A was discovered in a complex with ezrin and actin in placenta microvilli. CLIC5A is also greatly enriched in kidney glomeruli and is essential for assembly of the ezrin/NHERF2/podocalyxin complex at the apical domain of glomerular podocyte foot...
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Fall 2018
Chloride intracellular channel (CLIC) proteins comprise six members CLIC1–CLIC6 in mammals and mediate functions not fully known. Their founding member was isolated from bovine kidney using the chloride channel inhibitor indanyloxyacetic acid-94, so CLICs were assumed to be typical anion...