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Fall 2016
The p53 family of tumor suppressors is an important group of transcription factors preventing the development of cancer by targeting cell-cycle arrest and apoptosis mediator proteins for transcription. The most studied, p53, is frequently inactivated in carcinomas by mutation or genetic...
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The Regulation of p53 by E3 ligases MDM2 and CHIP in Breast Cancer: Analysis of the Role of Hsp70 and Hsp90
DownloadSpring 2016
Tumor suppressor p53 is commonly mutated in breast cancer. Mutant p53 protein is highly stable and oncogenic. This study aims to understand the underlying mechanism of the regulation and stabilization of mutant p53 protein particularly folded mutant p53 R280K. The data showed a possible...