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Background The delivery of optimal medical care to children is dependent on the availability of child relevant research. Our objectives were to: i) systematically review and describe how children are handled in reviews of drug interventions published in the Cochrane Database of Systematic Reviews...
Introduction A research-practice gap exists between what is known about conducting methodologically rigorous randomized controlled trials (RCTs) and what is done. Evidence consistently shows that pediatric RCTs are susceptible to high risk of bias; therefore novel methods of influencing the...
Research is crucial for the development of treatment guidelines. Informed consent is an essential component to ensure the ethical integrity of research. An ideal informed consent should meet three requirements; disclosure of adequate information about the study, subjects understand the...