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Skip to Search Results- 3Chakrabarti, Subhadeep
- 3Proctor, Spencer D.
- 3Wu, Jianping
- 2AlZahal, Ousama
- 2Dionissopoulos, Louis
- 2Field, Catherine J.
- 38Graduate and Postdoctoral Studies (GPS), Faculty of
- 38Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 16Agricultural, Food and Nutritional Science, Department of
- 16Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Pharmacy and Pharmaceutical Sciences, Faculty of
- 2Medicine and Dentistry, Faculty of
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Fall 2023
The calving transition is a challenging period for dairy cows characterized by negative energy balance, metabolic dysfunction, and inflammation, each of which may compromise milk production. Despite extensive research in this area, much is still unknown on how to best manage this period. The...
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Investigating the role of coiled-coil domain containing protein 3 (CCDC3), a novel secreted protein, in endothelial inflammation
DownloadFall 2015
Endothelial inflammation is critical in the initiation and progression of atherosclerosis and other cardiovascular diseases (CVDs). Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that induces endothelial inflammation via activation of nuclear factor κB (NF-κB) signaling....
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Lifestyle Variables, Non‐traditional Cardiovascular Risk Factors, and the Metabolic Syndrome in an Aboriginal Canadian Population
Download2006-01-05
Liu, Juan, Young, T. Kue, Zinman, Bernard, Harris, Stewart B., Connelly, Philip W., Hanle, Anthony J.G.
"Objective: To examine lifestyle factors associated with metabolic syndrome (MetS) and to explore the relationships between MetS and non‐traditional cardiovascular disease risk factors [adiponectin, leptin, C‐reactive protein (CRP), interleukin‐6 (IL‐6), and serum amyloid A (SAA)] in an isolated...
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Method, degree and lineage of prenatal maternal stress: effects on inflammatory and stress marker profiles of reproductive tissues and pregnancy outcomes
DownloadSpring 2023
Lopes, Nayara Gabriela Antunes
Prenatal maternal stress (PNMS) is any type of stress that pregnant women and animals experience. It was reported that over 70% of pregnant women experience low to moderate stress, while 6% experience high stress. Growing evidence indicates that PNMS influences maternal and offspring health...
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Milk-derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) promote adipocyte differentiation and inhibit inflammation in 3T3-F442A cells
Download2015
Chakrabarti, Subhadeep, Wu, Jianping
Milk derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) have shown promise as anti-hypertensive agents due to their inhibitory effects on angiotensin converting enzyme (ACE). Due to the key inter-related roles of hypertension, chronic inflammation and insulin resistance in the...
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Spring 2020
The human neuraminidases (NEU1, NEU2, NEU3, and NEU4) are a family of enzymes implicated in pathologies including cancer and diabetes. Our group has developed selective inhibitors for these enzymes that have been employed as tools to understand their biological roles. Several reports have linked...
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Molecular imaging of cyclooxygenase-2 (COX-2) and autotaxin (ATX) in cancer using positron emission tomography (PET)
DownloadFall 2020
Positron emission tomography (PET) relies on the use of β+-emitting radionuclide-bearing molecules congregating and decaying at a specific site of interest. Use of these molecules, called radiotracers, which target common tumor characteristics has become a pillar in the diagnosis of cancer and...
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Fall 2016
Macrophages are the primary cells of innate immunity that provide the first line of defence against any external stimuli. Their phagocytic properties enable them to engulf invading microbes or foreign particles. The phagocytic capability of macrophages plays a major role in interfering with drug...
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Neutrophil elastase alters the murine gut mirobiota resulting in enhanced Salmonella colonization
Download2012
Hartmann, Martin, Sekirov, Inna, Finlay, B. Brett, Al-Zahrani, Fatimah, Willing, Benjamin P., Ferreira, Rosana B. R., Gill, Navkiran, Antunes, L. Caetano M.
The intestinal microbiota has been found to play a central role in the colonization of Salmonella enterica serovar Typhimurium in the gastrointestinal tract. In this study, we present a novel process through which Salmonella benefit from inflammatory induced changes in the microbiota in order to...
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Fall 2023
The overarching idea of this thesis stemmed from previous work in our lab, where it was noticed that females and males exhibited different disease trajectories in a model of Multiple Sclerosis. Combined with our observation of different outcome metrics for peripheral nociception suggested that...