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Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
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Fall 2017
Prion disease, or transmissible spongiform encephalopathy (TSE), is a type of neurodegenerative disease for which there is no treatment and which is invariably fatal. Prion diseases are distinct in the field of biology and medicine, not only because they can be sporadic, infectious, or inherited,...
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Spring 2016
Background: Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin (HTT) protein. Mutant huntingtin (mHTT) accumulates as toxic oligomers and aggregates inside the cell, when it is not removed efficiently by selective...