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Spring 2011
Niemann-Pick Type C (NPC) disease is an autosomal recessive disorder that results in accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/Ls), leading to progressive neurodegeneration and premature death. Microglia are resident immune cells of the central nervous system, which...
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Fall 2014
An individual’s body weight is tightly regulated by balancing food intake with energy expenditure. This is accomplished in part by secretion of the hormone leptin by adipocytes, an excess of which signals to reduce appetite and increase activity through action in the hypothalamic region of the...
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Spring 2024
Recovery after stroke depends on the extent of neuronal regeneration and myelination of existing and newly differentiated neurons. Regeneration process is governed by various factors released from glial cells. During an injury, glial cells activate and form a glial scar surrounding the lesion...