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Respiratory Syncytial Virus infection biases the immune response in favor of Th2: the role of Indoleamine 2, 3-dioxygenaseDownload
Infants that develop severe bronchiolitis due to Respiratory Syncytial Virus (RSV) are at increased risk of developing asthma later in life. To begin my studies in vitro, purified RSV stock was needed. My first study established the critical steps in RSV purification to determine a procedure that...
Understanding implementation processes of clinical pathways and clinical practice guidelines in pediatric contexts: A study protocolDownload
Background: Canada is among the most prosperous nations in the world, yet the health and wellness outcomes of Canadian children are surprisingly poor. There is some evidence to suggest that these poor health outcomes are partly due to clinical practice variation, which can stem from failure to...
This thesis examines the pathophysiology of asthma, attempts to determine the cellular mechanisms behind viral-induced immune memory mediated asthma exacerbations, and investigates urinary metabolomic biomarkers of asthma and neonatal hypoxia.
Virus Induced Asthma Exacerbations: Immunologic Mechanisms and Metabolomic Biomarkers
Asthma is a complex multifaceted chronic inflammatory disease that is characterized clinically by reversible airflow obstruction, shortness of breath, coughing, and wheezing. Asthma is the most common chronic disease in children, and is differentiated into many phenotypes with multiple triggers....
Epidemiological studies correlate vitamin D deficiency with asthma severity. Calcitriol modulates receptor and cytokine expression from various leukocytes in an anti-inflammatory manner. Despite eosinophil activity during mucosal inflammation, knowledge on the direct effect of calcitriol on this...