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- 3Aryl Hydrocarbon Receptor
- 1Arsenic metabolites
- 1Aryl Hydrocarbon Receptor antagonists from natural source
Several studies have examined the toxic effects of individual aryl hydrocarbon receptor (AhR) ligands, yet there are relatively few reports of the combined toxic effects of AhR ligands and other environmental co-contaminants, such as heavy metals. Chromium (Cr+6) is one of the major environmental...
Dioxins are widespread environmental contaminants that have been linked to a variety of deleterious effects on human health including increased cancer rates via aryl hydrocarbon receptor (AhR)-dependent mechanism. AhR is a transcription factor that regulates the expression of the...
Aryl hydrocarbon receptor (AhR) ligands and heavy metals are environmental co-contaminants and their molecular interaction may disrupt the coordinated regulation of AhR-dependent phase I and II drug metabolizing enzymes. As such, the effect of the heavy metal, As(III), on the AhR-regulated genes...