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- 31Graduate Studies and Research, Faculty of
- 31Graduate Studies and Research, Faculty of/Theses and Dissertations
- 2Helmholtz-Alberta Initiative
- 2Helmholtz-Alberta Initiative/Journal Articles & Research Abstracts (Helmholtz-Alberta Initiative)
- 2Biological Sciences, Department of
- 2Biological Sciences, Department of/Journal Articles (Biological Sciences)
Regulation of Pancreatic β-cell Life and Death in the Context of Type 2 Diabetes: Study of the Potential Implication of the Orphan Nuclear Receptor NR4A3/Nor1 and the NZF Transcription Factor ST18.Download
Background: The insulin-secreting pancreatic beta-cell plays a central role in the maintenance of glucose homeostasis and in the pathogenesis of both type 1 and type 2 diabetes mellitus. In both cases, production of pro-inflammatory cytokines causes beta-cell apoptosis, which results in the...
Retrograde signaling mechanisms of nerve growth factor regulating the survival and apoptosis of sympathetic neuronsDownload
The survival of several neuron populations during development, including sympathetic neurons, is strictly regulated by neurotrophins such as nerve growth factor (NGF) released from innervation targets. NGF activates its receptor, TrkA, at axon terminals, to generate signals that are transmitted...
Targeting Phosphatidylserine for Positron Emission Tomography Imaging of Cell Death: Annexin V versus Phosphatidylserine-Binding PeptidesDownload
There is currently no clinically approved, widely used molecular imaging agent for in vivo detection of cell death. Such an agent would be highly useful for early assessment of treatment efficacy in cancer patients, as well as for monitoring many other diseases in which cell death plays an...
Apoptosis serves as a powerful defense against damaged and unwanted cells. The family of Bcl-2 proteins plays a key role in the regulation of apoptosis at the mitochondria. Members of the Bcl-2 family include pro- and anti-apoptotic members that collectively determine the state of the cell....
The Role of Forkhead Box Transcription Factors in Zebrafish Ocular Development and the Superior Ocular FissureDownload
Ocular development is a tightly orchestrated process that is dependent upon precise environmental and genetic factors. Disruption of this can result in microphthalmia, anophthalmia and coloboma (MAC), which is a spectrum of congenital ocular disease with lifelong consequences affecting sight. In...
Toxicity of untreated and ozone-treated oil sands process-affected water (OSPW) to early life stages of the fathead minnow (pimephales promelas)
Tumour-stromal interactions: Integrins and cell adhesions as modulators of mammary cell survival and transformationDownload
Stromal–epithelial interactions modulate mammary epithelial cell (MEC) growth and apoptosis by influencing cell adhesion and tissue organization. Perturbations in the mammary stroma and cell adhesion characterize breast tumors and underlie the altered tissue organization, disrupted tissue...