Search
Skip to Search Results- 2Veldhoen, Richard
- 1Abdualmjid,Reem J
- 1Abdurrahim, Amna E.
- 1Airo, Adriana M
- 1Allen, D. M.
- 1Allison, W. T.
- 42Graduate and Postdoctoral Studies (GPS), Faculty of
- 42Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 2Biological Sciences, Department of
- 2Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 1Pharmacy and Pharmaceutical Sciences, Faculty of
- 1Pharmacy and Pharmaceutical Sciences, Faculty of/Journal Articles (Pharmacy and Pharmaceutical Sciences)
-
Retrograde signaling mechanisms of nerve growth factor regulating the survival and apoptosis of sympathetic neurons
DownloadFall 2009
The survival of several neuron populations during development, including sympathetic neurons, is strictly regulated by neurotrophins such as nerve growth factor (NGF) released from innervation targets. NGF activates its receptor, TrkA, at axon terminals, to generate signals that are transmitted...
-
Fall 2017
Protein prenylation is the post-translational addition of isoprenoid lipid moieties to proteins, which regulates their subcellular localization and function. Farnesyl or geranylgeranyl isoprenoids are covalently linked to cysteines residues in a C-terminal prenylation recognition sequence in...
-
Targeting Phosphatidylserine for Positron Emission Tomography Imaging of Cell Death: Annexin V versus Phosphatidylserine-Binding Peptides
DownloadSpring 2016
There is currently no clinically approved, widely used molecular imaging agent for in vivo detection of cell death. Such an agent would be highly useful for early assessment of treatment efficacy in cancer patients, as well as for monitoring many other diseases in which cell death plays an...
-
Fall 2019
Breast cancer is the leading cause of death among women worldwide. Fortunately, death rates have been declining since 1990, due to the increase in early detection, testing, and improved treatment. However, despite the advancement of targeted and hormone therapies for certain molecular sub-types...
-
Spring 2017
Apoptosis serves as a powerful defense against damaged and unwanted cells. The family of Bcl-2 proteins plays a key role in the regulation of apoptosis at the mitochondria. Members of the Bcl-2 family include pro- and anti-apoptotic members that collectively determine the state of the cell....
-
The Role of Forkhead Box Transcription Factors in Zebrafish Ocular Development and the Superior Ocular Fissure
DownloadFall 2014
Ocular development is a tightly orchestrated process that is dependent upon precise environmental and genetic factors. Disruption of this can result in microphthalmia, anophthalmia and coloboma (MAC), which is a spectrum of congenital ocular disease with lifelong consequences affecting sight. In...
-
Tumour-stromal interactions: Integrins and cell adhesions as modulators of mammary cell survival and transformation
Download2001
Chrenek, Micah A., Weaver, Valerie M., Wong, Paul
Stromal–epithelial interactions modulate mammary epithelial cell (MEC) growth and apoptosis by influencing cell adhesion and tissue organization. Perturbations in the mammary stroma and cell adhesion characterize breast tumors and underlie the altered tissue organization, disrupted tissue...