Search
Skip to Search Results- 1Banadyga, Logan Elliott
- 1Campbell, Stephanie D
- 1Hu, Qian
- 1Lee, Jason KH
- 1Mehta, Ninad
- 1Pearson, Joel Dylan
-
Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
-
Fall 2012
Approximately 70% of patients infected with hepatitis C virus (HCV) develop chronic infection, which has been reported to be due to impaired specific T cell responses. Myeloid dendritic cells (mDCs) are potent antigen-presenting cells that regulate T cell responses, however their role during...
-
Fall 2013
Deregulated TNF signaling with elevated or decreased levels of TNF-induced apoptosis causes numerous inflammatory and cancerous diseases. Thus, there is a clear need to identify cellular proteins that regulate cell fate in the presence of TNF. RNA interference technology provides an excellent...
-
Spring 2013
The activation of caspases is an important step not only in apoptosis induction, but in cellular processes such as proliferation, differentiation, and the immune response. Here, we show that the AP-1 family transcription factor JunB is cleaved and dephosphorylated in a caspase-dependent manner in...
-
Investigating the functions of the c-Jun and JunB transcription factors in classical Hodgkin Lymphoma
DownloadFall 2016
Classical Hodgkin lymphoma (cHL) is characterized by the presence of abnormal mononuclear Hodgkin and multinuclear Reed-Sternberg (HRS) cells, which are thought to be derived from clonally expanded germinal center B cells. The tumour cells have been demonstrated to have various signalling...
-
Spring 2012
Apoptosis, an evolutionarily conserved cell death programme, is a potent barrier against virus infection. Central to this process are mitochondria, which harbour cytochrome c and other apoptosis-inducing factors. Once released, these factors activate a caspase cascade that culminates in cell...
-
Poxviral manipulation of Bcl-2 proteins: fowlpox virus FPV039 and deerpox virus DPV022 inhibit apoptosis by neutralising Bak and Bax, while Noxa contributes to vaccinia virus-induced apoptosis
DownloadSpring 2011
Poxviruses are renowned for encoding proteins that modulate virtually every aspect of the host immune system. One effective barrier against virus infection is apoptosis, a form of programmed cell death. Apoptosis is controlled at the mitochondria by pro- and anti-apoptotic members of the highly...
-
Spring 2017
Apoptosis serves as a powerful defense against damaged and unwanted cells. The family of Bcl-2 proteins plays a key role in the regulation of apoptosis at the mitochondria. Members of the Bcl-2 family include pro- and anti-apoptotic members that collectively determine the state of the cell....
-
Understanding the function of the JunB transcription factor in anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma
DownloadFall 2013
Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is a non-Hodgkin lymphoma thought to arise from an activated T lymphocyte. This lymphoma is characterized by the presence of chromosomal translocations involving the ALK tyrosine kinase, which generate oncogenic...