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Skip to Search Results- 1Alvarado, Laura
- 1Bamford, Jeremy, Andrew
- 1Bergquist, Austin J
- 1Caliaperumal, Jayalakshmi
- 1Clair, Joanna
- 1Clark, Darren
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Neuronal Mechanisms of Hyperexcitability in Individuals with Spasticity after Spinal Cord Injury and Individuals with Bruxism
DownloadFall 2013
Motoneuron hyperexcitability is a characteristic of several different motor disorders. We examined neuronal mechanisms of hyperexcitability in two of these disorders: spasticity after spinal cord injury (SCI) and bruxism. Involuntary muscle spasms after SCI occur as a result of uncontrolled...
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Peripheral and central contributions to evoked contractions during neuromuscular electrical stimulation
DownloadFall 2013
The present thesis examined two general questions regarding neuromuscular electrical stimulation (NMES): 1) How can the delivery of NMES be optimised to enhance synaptic motor unit recruitment via reflex pathways (central pathways) and 2) Can motor unit recruitment through central pathways...
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Fall 2013
This thesis explores strategies to promote neuronal plasticity in a rat model of cervical spinal cord injury (SCI) in an effort to achieve improved recovery of skilled forelimb use. I focused on investigating how motor pathways disrupted by an SCI may connect to spared, lesion-bridging relay...
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Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat
DownloadSpring 2011
Injury to the cervical spinal cord is a devastating event that results in a transient to permanent loss of sensory and motor functions following injury. Moderate recovery has been reported to occur in individuals and in animal models after spinal cord injury (SCI). One approach to promote...
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Fall 2010
In this thesis sensorimotor integration in the human spinal cord was investigated in the intact (Chapters 2 and 3) and injured nervous systems (Chapter 4-stroke; Chapter 5-spinal cord injury (SCI)). In Chapter 2, I characterized a short-latency reflex pathway between sensory receptors of the...
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The role fo the adrenergic system in the recovery of motoneuron excitability and spasms after spinal cord injury
DownloadSpring 2011
Brainstem derived noradrenaline (NA) in the spinal cord functions both to increase motoneuron excitability, by facilitating calcium-mediated persistent inward currents (Ca PICs), and to inhibit sensory afferent transmission to motoneurons (excitatory postsynaptic potentials; EPSPs). Spinal cord...
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Fall 2010
Brainstem derived serotonin (5-HT) normally facilitates spinal motoneuron excitability and inhibits sensory afferent transmission and associated spinal reflexes. Because the 5-HT innervation of the spinal cord is almost exclusively derived from brainstem neurons, spinal cord injury leads to an...
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Spring 2016
Mild therapeutic hypothermia (HYPO), decreasing brain temperature to 32-35°C, is the gold standard neuroprotectant against ischemia. Cooling also ameliorates several cell death mechanisms in other types of brain injury (e.g., traumatic brain injury). As with many other neuroprotectants, HYPO not...