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Blood-brain barrier permeability following intracerebral hemorrhage is related to local ion dyshomeostasis
DownloadFall 2017
Background: Increased blood-brain barrier (BBB) permeability is seen after intracerebral hemorrhage (ICH). Following ICH, BBB dysfunction occurs due to direct (e.g. mechanical damage) and indirect (e.g. inflammation) injury. Damage to the BBB prevents maintenance of brain homeostasis. This thesis...
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Fall 2020
Intracerebral hemorrhage (ICH), when a blood vessel ruptures within the brain, affects approximately 15% of stroke victims in Canada. There are no proven neuroprotective treatments ICH but two therapies, therapeutic hypothermia (TH) and iron-chelators, have gained preclinical and clinical...
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Spring 2016
Mild therapeutic hypothermia (HYPO), decreasing brain temperature to 32-35°C, is the gold standard neuroprotectant against ischemia. Cooling also ameliorates several cell death mechanisms in other types of brain injury (e.g., traumatic brain injury). As with many other neuroprotectants, HYPO not...