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Fall 2010
Hyperthermia worsens outcome after ischemia. While it seems reasonable that hyperthermia would also worsen outcome after intracerebral hemorrhage (ICH), clinical studies attempting to find a causative relationship between hyperthermia and outcome have been inconclusive. We induced ICH with an...
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Blood-brain barrier permeability following intracerebral hemorrhage is related to local ion dyshomeostasis
DownloadFall 2017
Background: Increased blood-brain barrier (BBB) permeability is seen after intracerebral hemorrhage (ICH). Following ICH, BBB dysfunction occurs due to direct (e.g. mechanical damage) and indirect (e.g. inflammation) injury. Damage to the BBB prevents maintenance of brain homeostasis. This thesis...
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Fall 2010
There are two types of stroke: ischemic and hemorrhagic. Intracerebral hemorrhage (ICH) accounts for about 15% of all strokes and is often severe. Currently no treatments are available to reduce injury, but rehabilitation may improve recovery. Most studies focus on ischemia, putting little...
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The Effects of a Western Diet on Stroke Severity and Functional Outcome Following Global Ischemia in Rats
DownloadFall 2009
The present thesis investigated the effects of a western diet (WD) on cell death and functional outcome following global ischemia in rats. Experiment 1 assessed the effects of a 60-day WD regimen on temperature, activity and glucose levels in normal rats. Experiment 2 evaluated the influence of a...