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- 1Absorption--Mathematical models
- 1Activation Energy
- 1Alkylation
- 1Carbon
- 1Carbon Nucleophiles
- 1Browne, Denis Wakefield.
- 1Chea, JongMyong
- 1Clive, Derrick J. L.
- 1Clive, Derrick L. J.
- 1Houk, K. N.
- 1Jiménez-Osés, Gonzalo
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Computations Reveal That Electron-Withdrawing Leaving Groups Facilitate Intramolecular Conjugate Displacement Reactions by Negative Hyperconjugation.
Download2016-01-01
Noey, Elizabeth L., Jiménez-Osés, Gonzalo, Clive, Derrick J. L., Houk, K. N.
Intramolecular conjugate displacement (ICD) reactions, developed by the Clive group, form carbocycles and cyclic amines by intramolecular nucleophilic attack on a Michael acceptor with an allylic leaving group. Quantum mechanical investigations with density functional theory show that ICDs...
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2015-01-01
Chea, JongMyong, Clive, Derrick L. J.
N-Boc (S)-proline was converted into (2S)-2-[(phenylselanyl)methyl]pyrrolidine which was alkylated on nitrogen with 2-bromo-1-(4-methoxyphenyl)ethan-1-one. Reaction with vinyllithium, 6-exo-trigonal radical cyclization (Bu3SnH, AIBN, PhMe, 110 °C), dehydration (P2O5, H3PO4) and demethylation...