Search
Skip to Search Results- 27Alzheimer's disease
- 11Cognitive impairment
- 4Dementia
- 3Amyloid precursor protein
- 3Interventions
- 3Meta-analysis
- 22Graduate and Postdoctoral Studies (GPS), Faculty of
- 22Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 10Nursing, Faculty of
- 8Nursing, Faculty of/Chronicity
- 2Rehabilitation Medicine, Faculty of
- 2Rehabilitation Medicine, Faculty of/Speech Pathology and Audiology
-
2016-03-23
Muc, Nausha, Suleman, Salima, Kim, Esther, Dahlke, Kaetlyn, Lorenz, Allison
Aphasia is a language disorder, but it may also be accompanied by subtle cognitive impairments including deficits in working memory (WM). These cognitive and WM impairments are hard to quantify as traditionally, performance is assessed with a verbal or motoric response. These measures can be...
-
Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
-
Fall 2019
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptide. It has been proposed that AD pathology is transmissible by a “prion-like” mechanism through extracellular vesicles (EVs) that contain Aβ. In this context, EVs describe both microvesicles and exosomes,...
-
Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
-
Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
-
Fall 2013
Background: Ischemic stroke is associated with cognitive impairment, but the acute cognitive sequelae of transient ischemic attack (TIA) and minor stroke is unknown. We hypothesized that transient cognitive impairment can be predicted by diffusion-weighted imaging (DWI) lesion volume. Methods:...
-
Fall 2018
Amyotrophic Lateral Sclerosis (ALS) involves the progressive loss of upper and lower motor neurons. Frontotemporal lobar degeneration (FTLD) has been reported in a considerable proportion of patients, manifesting as cognitive and behavioural impairment in at least 25-50%, with 10-15% patients...