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Skip to Search Results- 2Affinity maturation
- 1AID
- 1Activation-induced cytidine deaminase
- 1Aicda
- 1Class switch recombination
- 1Germinal centre
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Melano-macrophage characterization and their possible role in the goldfish (Carassius auratus) antibody affinity maturation
DownloadSpring 2013
During the antibody affinity maturation process, changes to the immunoglobulin genes are initiated by the B-cell specific enzyme activation-induced cytidine deaminase (AID). These changes are randomly generated and produce antibodies with different affinities for the antigen. In mammals, this...
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Transcriptional regulation of the zebrafish activation-induced cytidine deaminase (AID) gene
DownloadFall 2012
Activation-induced cytidine deaminase (AID, encoded by Aicda) mediates affinity maturation of immunoglobulin genes. Early studies in mammals indicated that the transcription of Aicda was regulated by a number of transcriptional regulatory regions, including a B-cell specific enhancer in the...