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Skip to Search Results- 26Fatty acids
- 22Electrospray ionization mass spectrometry
- 12Affinity
- 6Carbohydrates
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- 26Chemistry, Department of
- 26Chemistry, Department of/Journal Articles (Chemistry)
- 21Graduate and Postdoctoral Studies (GPS), Faculty of
- 21Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 5Roy Berg Kinsella Research Ranch
- 5Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
- 5Department of Agricultural, Food, and Nutritional Science
- 2Department of Chemical and Materials Engineering
- 2Department of Chemistry
- 2Department of Medicine
- 2Department of Oncology
- 2Department of Pharmacology
- 1Ambrose, Divakar (Department of Agricultural, Food and Nutritional Science)
- 1Baker, Kristi (Oncology)
- 1Bressler, David C. (Agricultural, Food and Nutritional Science)
- 1Deutsch, Clayton (Mining Engineering)
- 1Dyck, Jason RB (Pediatrics)/ McAlister, Finlay A (Medicine)
- 1Febbraio,Maria (Dentistry)
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2015
El-Hawiet, Amr, Klassen, John S., N. Kitova, Elena N.
The affinities of the most abundant oligosaccharides found in human milk for four bacterial exotoxins (from Vibrio cholerae and pathogenic Escherichia coli) were quantified for the first time. Association constants (Ka) for a library of 20 human milk oligosaccharides (HMOs) binding to Shiga toxin...
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma Receptors
DownloadSpring 2019
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
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Reliable determinations of protein-ligand interactions by direct ESI-MS measurements: Are we there yet?
Download2012
El-Hawiet, Amr, Klassen, John S., Kitova, Elena N., Schnier, Paul D.
The association-dissociation of noncovalent interactions between protein and ligands, such as other proteins, carbohydrates, lipids, DNA, or small molecules, are critical events in many biological processes. The discovery and characterization of these interactions is essential to a complete...
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Reliable determinations of protein-ligand interactions by direct ESI-MS measurements: Are we there yet?
Download2012
Klassen, John S., Kitova, Elena N., Schnier, Paul D., El-Hawiet, Amr
The association-dissociation of noncovalent interactions between protein and ligands, such as other proteins, carbohydrates, lipids, DNA, or small molecules, are critical events in many biological processes. The discovery and characterization of these interactions is essential to a complete...
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2004
Wang, Z., Goonewardene L. A., Mir, P. S., Mir, Z., Okine, E. K., Marx, T., Spener, D.
The objective was to determine if end-of-test residual metabolizable energy intake (RMEI) is correlated with RMEI values calculated earlier in the test on steers fed two forage (silage) or four forage-grain diets. As the days on test increased the variation in RMEI decreased in all diets. In all...
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Fall 2010
Patients diagnosed with malignant glioma tumours have median survivals of 1.6 yrs and 5 months, respectively, highlighting the deadly nature of this disease. Despite aggressive multimodal treatment, patients with malignant glioma often present with secondary brain tumours at sites distal to the...
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Spring 2024
Background and Objective High-fat Western diets have been linked to the dysregulation of fatty acids (FA) and glucose intake in tissues, resulting in adverse metabolic outcomes such as obesity, insulin resistance, and atherosclerosis. There is a pressing need for new therapeutic approaches to...
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Screening anti-cancer drugs against tubulin using catch-and-release electrospray ionization mass spectrometry
Download2016
Kitova, Elena N., Klassen, John S., Winter, Philip, Tuszynski, Jack A., Darestani, Reza R.
Tubulin, which is the building block of microtubules, plays an important role in cell division. This critical role makes tubulin an attractive target for the development of chemotherapeutic drugs to treat cancer. Currently, there is no general binding assay for tubulin–drug interactions. The...
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Screening anti-cancer drugs against tubulin using catch-and-release electrospray ionization mass spectrometry
Download2016
Kitova, Elena N., Klassen, John S., Winter, Philip, Tuszynski, Jack A., Darestani, Reza R.
Tubulin, which is the building block of microtubules, plays an important role in cell division. This critical role makes tubulin an attractive target for the development of chemotherapeutic drugs to treat cancer. Currently, there is no general binding assay for tubulin–drug interactions. The...