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Skip to Search Results- 62Diabetes
- 24Lipids
- 22Electrospray ionization mass spectrometry
- 8Metabolic Syndrome
- 8Obesity
- 7Acute myeloid leukemia
- 57Graduate and Postdoctoral Studies (GPS), Faculty of
- 57Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 22Chemistry, Department of
- 22Chemistry, Department of/Journal Articles (Chemistry)
- 16Agricultural, Food and Nutritional Science, Department of
- 16Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 11Department of Agricultural, Food, and Nutritional Science
- 7Department of Medicine
- 7Department of Surgery
- 4Department of Pharmacology
- 4School of Public Health
- 3Faculty of Pharmacy and Pharmaceutical Sciences
- 2Brandwein, Joseph (Medicine)
- 2Johnson, Jeff A. (School of Public Health Sciences, University of Alberta)
- 2Proctor, Spencer (AFNS)
- 2Williams, Beverly (Faculty of Nursing, University of Alberta)
- 1Al Hamarneh, Yazid (Pharmacology)
- 1Anderson, Colin (Medical Microbiology and Immunology and Surgery)
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Deciphering the Biological Basis of Acute Myeloid Leukemia Relapse Using a Novel In-Vitro Study Model
DownloadSpring 2024
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy associated with a poor clinical outcome that is largely attributed to disease relapses. Treatment options for relapsed AML patients are limited; after relapse, the median survival is only ~6 months. The biology underlying...
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Fall 2012
Establishing mixed hematopoietic chimerism is a promising approach to develop donor-specific tolerance to transplanted organs. Establishing tolerance may eliminate the need for long-term immunosuppressive therapy, prevent chronic rejection and in the case of Type 1 Diabetes (T1DM), reverse...
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2019-12-10
Pepper, Andrew, Korbutt, Gregory
NFRF Exploration awarded in 2020: While the global incidence of type 1 diabetes (T1D) continues to rise, it is now clear that transplantation of human pancreatic islets of Langerhans, into the patients’ liver, can successfully restore glycemic control. Despite marked progress in clinical islet...
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Spring 2010
Interest in microfluidic platforms has surged as an alternative for sample preparation in the past two decades, with the potential for miniaturization, portability, automation, integration and parallelism driving this research. However, it is still very challenging to develop an integrated...
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Diabetes and Influenza-Attributable Illness: The Rationale for Targeted Influenza Vaccinations in Adults with Diabetes
DownloadFall 2012
While guidelines for seasonal influenza vaccinations single out working age (< 65) adults with diabetes, vaccination rates in this group remain below national targets. Historically, there has been limited evidence to support these guidelines. This dissertation comprises four studies investigating...
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Diabetes care and management in Indigenous populations in Canada – Summary report of a pan-Canadian policy roundtable November 1, 2017
Download2018-01-29
Institute of Health Economics, Craig, Rodger
This report provides a summary of the proceedings from the IHE roundtable on diabetes care and management in Indigenous populations in Canada, held on November 1, 2017. The roundtable aimed to: discuss and share learnings and promising practices from successful community-led diabetes programs,...
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2000-04-01
Sellers, Elizabeth, Eisenbarth, George, Young, T. Kue, Dean, Heather J.
"Type-2 diabetes is increasing in aboriginal children and adolescents and must be distinguished from type-1 diabetes in this population. The absence of diabetes-associated autoantibodies supports the clinical impression of type-2 diabetes in the affected members of this population." (as cited in...
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Diabetes-prone BioBreeding rats do not have a normal immune response when weaned to a diet containing fermentable fibre
Download2004
Bell, Rhonda C., Field, Catherine J., Stillie, RoseMarie
Diet is known to modulate the development of diabetes in diabetes-prone BioBreeding (BBdp) rats. The objective of the present study was to determine the effect of fermentable fibre (FF) on immune function in BBdp and diabetes-resistant BioBreeding (BBdr) rats after weaning. Weanling BBdp...
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Dietary fish oil reduces glomerular injury and improves elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome
Download2012
Proctor, Spencer D., Borthwick, Faye, Lu, Jing, Aukema, Harold
We have previously shown nutritional intervention with fish oil (n-3 PUFA) to reduce numerous complications associated with the metabolic syndrome (MetS) in the JCR:LA-corpulent (cp) rat. In the present study, we sought to explore the potential role of fish oil to prevent glomerulosclerosis in...
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Dissociation kinetics of the streptavidin-biotin interaction measured using direct electrospray ionization mass spectrometry analysis
Download2013
Kitova, Elena N., Klassen, John S., Deng, Lu
Dissociation rate constants (koff) for the model high affinity interaction between biotin (B) and the homotetramer of natural core streptavidin (S4) were measured at pH 7 and temperatures ranging from 15 to 45 °C using electrospray ionization mass spectrometry (ESI-MS). Two different approaches...