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Skip to Search Results- 1Chadwick, Caylin Isabelle
- 1Dorfman, Tamara L.
- 1Duggleby, Wendy Diane.
- 1Dworsky-Fried, Zoë
- 1Iden, Jason, B.
- 1Salla, Mohamed
- 1Baksh, Shairaz (Pediatrics)
- 1Clayton T. Dickson (Psychology, Physiology, Anesthesia and Pain Medicine, Neuroscience and Mental Health Institute)
- 1Dr. Gary Lopaschuk/Dr. Katherine Kavanagh
- 1Kerr, Bradley (Anesthesiology & Pain Medicine)
- 1Kerr, Bradley (Neuroscience and Mental Health Institute, Anesthesiology and Pain Medicine, Pharmacology)
- 1Light, Peter (Pharmacology)
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Chronic Pain in a Mouse Model of Multiple Sclerosis: Contributions of the Kappa Opioid System
DownloadFall 2021
The perception of pain is a multimodal experience that is encoded by regions of the central nervous system (CNS) that are involved in sensation, affect, and cognition. Chronic pain is not merely the persistence of pain, but a debilitating condition that is associated with neurochemical...
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Fall 2010
This study aimed to examine potential mechanisms for glucocorticoid (GC)-induced decreases in glucose clearance, and to determine if a reduction in oxidative stress load via dietary pre-treatment with an antioxidant-rich diet has a positive net effect on glucose tolerance following a sub-chronic...
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Instruments for Scoring Pain, Non-Pain Related Distress, Analgesia, and Sedation in Pediatric Mechanically Ventilated Patients and their Efficacy and Effectiveness in Practice: A Systematic Review
DownloadFall 2012
Objective pain and sedation assessment scales to standardize measures of distress in mechanically ventilated pediatric patients are increasingly available, but few have been evaluated for efficacy and effectiveness in this population. The purpose of paper one was to identify and evaluate...
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Molecular and Epigenetic Insights into RASSF1A Regulated Pathways in Inflammatory Bowel Disease
DownloadFall 2018
Inflammatory Bowel Disease (IBD) is an idiopathic non-curable disease characterized by pain, chronic diarrhea, rectal bleeding with weight loss and erosion of the colon in severe cases. In many cases, IBD is a chronic relapsing inflammatory disorder of the gastrointestinal tract that usually...
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Fall 2015
Youssef, Nermeen Hosny Ibrahim
Plasma membrane ATP-sensitive potassium (KATP) channels are found in many excitable cell types where they couple cellular metabolism and membrane excitability. . Studies on KATP deficient mice show that parameters of cardiac mechanical function are similar to those of wild-type mice under basal...
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Pain and analgesia in experimental autoimmune encephalomyelitis: Contribution of the central nucleus of the amygdala
DownloadSpring 2021
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation, degeneration and demyelinating lesions within the central nervous system. Chronic pain is a highly prevalent symptom associated with MS, affecting 50-80% of patients over the course of their disease....
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Regulation of Cardiac Gap Junctional Communication: Metabolic regulation of Cx40 and Cx43 via phosphorylation
DownloadFall 2015
Alterations in myocardial metabolism and cardiac electrophysiology associated with structural heart disease generate lethal arrhythmias. Differential levels of energy (ATP) supply and demand are generated with structural heart disease that is expected to activate 5’-amp activated protein kinase...
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Fall 2023
Sleep is a vital neurobiological process, yet despite its fundamental significance, delineating the endogenous neural pathways involved has been slow to progress due to a lack of diverse sleep models. Anesthesia, which has direct behavioural parallels to natural sleep, and which is often linked...